Limit search to items available for checkout
Title Introductory adaptive trial designs : a practical guide with R / Mark Chang.
Imprint Boca Raton : CRC Press, [2015]


 Internet  Electronic Book    AVAILABLE
Description 1 online resource (xiii, 218 pages) : illustrations
Series Chapman & Hall/CRC biostatistics series
Chapman & Hall/CRC biostatistics series.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Clinical trials -- Design.
Clinical trials -- Computer simulation.
Clinical trials -- Statistical methods.
Adaptive sampling (Statistics)
R (Computer program language)
Clinical Trials as Topic.
Research Design.
Models, Statistical.
Contents Front Cover; Contents; Preface; 1. Introduction; 2. Classical Design; 3. Two-Stage Adaptive Confirmatory Design Method; 4. K-Stage Adaptive Confirmatory Design Methods; 5. Sample-Size Reestimation Design; 6. Special Two-Stage Group Sequential Trials; 7. Pick-the-Winners Design; 8. The Add-Arms Design; 9. Biomarker-Adaptive Design; 10. Response-Adaptive Randomization; 11. Adaptive Dose-Escalation Trial; 12. Deciding Which Adaptive Design to Use; 13. Monitoring Trials and Making Adaptations; 14. Data Analyses of Adaptive Trials; 15. Planning and Execution.
Appendix A: Thirty-Minute Tutorial to RAppendix B: R Functions for Adaptive Designs; Bibliography.
Summary All the Essentials to Start Using Adaptive Designs in No Time Compared to traditional clinical trial designs, adaptive designs often lead to increased success rates in drug development at reduced costs and time. Introductory Adaptive Trial Designs: A Practical Guide with R motivates newcomers to quickly and easily grasp the essence of adaptive designs as well as the foundations of adaptive design methods.
Other Title Print version: 9781498717465 1498717462