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E-BOOK
Title Bayesian designs for phase I-II clinical trials / Ying Yuan, the University of Texas, MD Anderson Cancer Center, Houston, Texas, USA, Hoang Q. Nguyen, the University of Texas, MD Anderson Cancer Center, Houston, Texas, USA, Peter F. Thall, the University of Texas, MD Anderson Cancer Center, Houston, Texas, USA.
Imprint Boca Raton : Taylor & Francis, [2016]
©20
©2016

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Description 1 online resource
Series Chapman & Hall/CRC biostatistics series
Chapman & Hall/CRC biostatistics series.
Note "A Chapman & Hall book."
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Subject Clinical trials -- Statistical methods.
Drugs -- Testing -- Statistical methods.
Bayesian statistical decision theory.
Clinical Trials, Phase I as Topic.
Clinical Trials, Phase II as Topic.
Statistics as Topic.
Bayes Theorem.
Dose-Response Relationship, Drug.
Genre Electronic books.
Contents 1. Why conduct phase I-II trials? -- 2. The phase I-II paradigm -- 3. Establishing priors -- 4. Efficacy : toxicity trade-off-based designs -- 5. Designs with late-onset outcomes -- 6. Utility-based designs -- 7. Personalized dose finding -- 8. Combination trials -- 9. Optimizing molecularly targeted agents -- 10. Optimizing doses in two cycles -- 11. Optimizing dose and schedule -- 12. Dealing with dropouts -- 13. Optimizing intra-arterial tPA -- 14. Optimizing sedative dose in preterm infants.
Other Author Nguyen, Hoang Q., author.
Thall, Peter F., author.
Other Title Print version: 9781498709552