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E-BOOK
Title Design and analysis of clinical trials for predictive medicine / edited by Shigeyuki Matgsui, Marc Buyse, Richard Simon.
Imprint Boca Raton, FL : CRC Press, [2015]
©2015

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Description 1 online resource
Series Chapman & Hall/CRC Biostatistics Series ; v. 72
Chapman & Hall/CRC biostatistics series.
Bibliog. Includes bibliographical references.
Note Available only to authorized UTEP users.
Vendor-supplied metadata.
Subject Clinical trials -- Analysis.
Clinical Trials as Topic -- methods.
Biomarkers.
Research Design.
Statistics as Topic -- methods.
Genre Electronic books.
Contents Section 1. Introductory overview -- section 2. Early clinical trials using biomarkers -- section 3. Phase III randomized clinical trials using biomarkers -- section 4. Analysis of high-dimensional data and genomic signature developments -- section 5. Randomized trials with biomarker development and validation -- section 6. Evaluation of surrogate biomarkers.
Summary An emerging clinical trials paradigm for predictive medicine involves the development of molecular diagnostics to enable the prediction of the effects of treatment or outcomes of individual patients. This book offers statistical guidance on conducting clinical trials for predictive medicine. It covers statistical topics relevant to the main clinical research phases for developing molecular diagnostics and therapeutics. The book explains how to identify molecular biomarkers using DNA microarrays, validate the developed biomarkers, and confirm their clinical utility in randomized clinical trials.
Other Author Matsui, Shigeyuki, editor.
Buyse, Marc E., editor.
Simon, Richard M., 1943- editor.
Other Title Print version: Matsui, Shigeyuki. Design and Analysis of Clinical Trials for Predictive Medicine. Hoboken : CRC Press, ©2015 9781466558151