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Title Handbook of methods for designing and monitoring dose finding trials / John O'Quigley, Alexia Iasonos, Björn Bornkamp.
Imprint Boca Raton, FL : CRC Press, [2017]


 Internet  Electronic Book    AVAILABLE
Description 1 online resource : illustrations
Series Handbooks of modern statistical methods
Chapman & Hall/CRC handbooks of modern statistical methods.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Vendor-supplied metadata.
Subject Drugs -- Dose-response relationship -- Handbooks, manuals, etc.
Clinical trials -- Statistical methods -- Handbooks, manuals, etc.
Dose-Response Relationship, Drug.
Maximum Tolerated Dose.
Clinical Trials, Phase I as Topic -- methods.
Clinical Trials, Phase II as Topic -- methods.
Drug Design.
Genre Electronic books.
Handbooks and manuals.
Contents Cover; Half Title; Title Page; Copyright Page; Contents; Editors; Preface; Contributors; I: Phase I designs; 1 Overview of Phase I Designs; 2 Model-Based Designs for Safety; 3 Dose-Finding Methods for Nonbinary Outcomes; 4 Dose-Finding Trials in Pediatric Oncology; II: More advanced Phase I and Phase I/II methodology; 5 Phase I/II Dose-Finding Designs with Efficacy and Safety Endpoints; 6 Designing Early-Phase Drug Combination Trials; 7 Dose-Schedule Finding in Early-Phase Clinical Trials; 8 Patient Heterogeneity in Dose-Finding Trials.
9 Nonparametric Optimal Design in Adaptive Dose-Finding Studies10 Practical Implementation: Protocol Development; III: Phase II Dose-Finding Trials; 11 Dose-Finding Studies in Phase II: Introduction and Overview; 12 The MCP-Mod Methodology: Practical Considerations and the DoseFinding R Package; 13 Designing Phase II Dose-Finding Studies: Sample Size, Doses, and Dose Allocation Weights; 14 Two-Stage Designs in Dose Finding; 15 Longitudinal Dose-Response Models; 16 Multiple Test Strategies for Comparing Several Doses with a Control in Confirmatory Trials.
Other Author Iasonos, Alexia, author.
Bornkamp, Björn, author.
Other Title Print version: O'Quigley, John. Handbook of methods for designing and monitoring dose finding trials. Boca Raton, FL : CRC Press, [2017] 1498746101 9781498746106
Other Title Methods for designing and monitoring dose finding trials