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Title Comprehensive Natural Products III : chemistry and biology / Editors-in-Chief: Hung-Wen (Ben) Liu and Tadhg P. Begley.
Imprint [San Diego, California] : Elsevier, 2020.


 Internet  Electronic Book    AVAILABLE
Edition 3rd edition.
Description 1 online resource (7 volumes, 4252 pages)
Note x-ray crystallography.
Available only to authorized UTEP users.
Description based on online resource; title from home page (Science direct, viewed August 7, 2020)
Subject Natural products.
Contents 9780081026915_WEB01 -- Comprehensive Natural Products III Chemistry and Biology -- Copyright -- Contents of Volume 1 -- Editors-in-Chief -- Volume Editors -- List of Contributors for Volume 1 -- Volume Contents -- Preface -- 1.01. Overview and Introduction -- 1.02. Bacterial Type IPolyketide Synthases -- 1.02.1. Preface -- 1.02.2. Introduction to the Complex Polyketides -- 1.02.3. Modular Polyketide Synthases and Relationship to Fatty Acid Synthases -- Modular PKSs: Variations on aTheme -- Trans-ATPKSs -- Modular PKS modules which iterate.
1.02.5. The 3D Architectures of PKS Modules/Subunits -- Structural Insights Into Intact PKS Modules -- Modular PKS Structural Biology: FutureGoals -- 1.02.6. Protein-Protein Interactions in ModularPKSs -- ACP-Centered Domain-Domain Interactions -- Interactions Between Modules/Subunits -- Intramolecular intermodular interactions -- Intermolecular intermodular interactions (or docking) -- 1.02.7. Programming of Modular Polyketide Biosynthesis -- 1.02.8. Modular PKS Synthetic Biology -- 1.02.9. Conclusions and Future Perspectives.
Acknowledgment -- References -- 1.03. Structural Biology of Tailoring Domains in Polyketide Synthases -- 1.03.1. Introduction -- 1.03.2. The KR Domain -- 1.03.3. The DH Domain -- 1.03.4. The ER Domain -- 1.03.5. The MT Domain -- 1.03.6. The EI Domain -- 1.03.7. The PS Domain -- 1.03.8. The PT Domain -- 1.03.9. The TE Domain -- 1.03.10. Conclusion -- References -- 1.04. Structural Basis of Acyl-Carrier Protein Interactions in Fatty Acid and Polyketide Biosynthesis -- 1.04.1. Introduction -- 1.04.2. Methods to Study ACP Interactions -- Chemoenzymatic Modification of theACP. Molecular Probes and Methods to Study ACP Interactions -- Cysteine-reactive pantetheine crosslinking probes -- Histidine-reactive pantetheine crosslinking probes -- Noncovalent pantetheine probes -- Caged pantetheine crosslinking probes -- Photoaffinity crosslinking probes -- Molecular Probes and Methods to Study ACP-Substrate Interactions -- Polyketone surrogates -- Solvatochromic probes -- Vibrational spectroscopic probes -- Structural Methods to Study ACP Interactions.
Summary "Comprehensive Natural Products III, Third Edition, updates and complements the previous two editions, including recent advances in cofactor chemistry, structural diversity of natural products and secondary metabolites, enzymes and enzyme mechanisms and new bioinformatics tools. Natural products research is a dynamic discipline at the intersection of chemistry and biology concerned with isolation, identification, structure elucidation, and chemical characteristics of naturally occurring compounds such as pheromones, carbohydrates, nucleic acids and enzymes. This book reviews the accumulated efforts of chemical and biological research to understand living organisms and their distinctive effects on health and medicine and to stimulate new ideas among the established natural products community."
Other Author Begley, Tadhg P., editor.
Liu, Hung-wen, 1952- editor.
Other Title Print version: Begley, Tadhg Comprehensive Natural Products III San Diego : Elsevier,c2020.