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Author Liu, Huiping.
Title Cancer stem cells : targeting the roots of cancer, seeds of metastasis, and sources of therapy resistance / Huiping Liu, Justin D. Lathia.
Imprint [London] : Academic Press is an imprint of Elsevier, 2016.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Subject Cancer cells.
Stem cells.
Contents Front Cover; Cancer Stem Cells; Cancer Stem Cells; Copyright; Dedication; Contents; List of Contributors; Foreword by Jane Visvader; Foreword by Stanton L. Gerson; Preface; Acknowledgments; I -- CSC Overview and Methodology; 1 -- Introduction: Cancer Stem Cells; INTRODUCTION; CANCER STEM CELL ORIGINS; Cancer Stem Cell Generation From a Single Cell of Origin; Two Models for Tumor Growth and Expansion; IDENTIFICATION OF THE CANCER STEM CELL POPULATION; Features of Cancer Stem Cell; Biomarkers for Cancer Stem Cell Identification; Key Signaling Pathways Involved in Cancer Stem Cell Maintenance.
MOUSE MODELS OF CANCER STEM CELL FUNCTIONPatient-Derived Xenograft Models; Germline Genetically Engineered Mouse Models; Somatic Genetically Engineered Mouse Models; Germline-Derived Allograft Models; Humanized Mouse Models; STRATEGIES FOR TARGETING CANCER STEM CELL; Protective Signaling Pathways; Immunotherapies Against Cell Surface Markers; Tumor Microenvironment-The Complicit Cells of the Cancer Stem Cell Niche; ATP-Binding Cassette Transporters: Multidrug and Redox Stress Resistance; FUTURE OF CANCER STEM CELL-DIRECTED THERAPIES; CONCLUSION; LIST OF ACRONYMS AND ABBREVIATIONS; References.
Reporter Systems Used for Enrichment and Analysis of Cancer Stem CellsSOX2; NANOG; OCT4; SORE6; NOTCH; TERT; s-SHIP; Alpha Fetoprotein; Transcription Factor/Lymphoid Enhancer Binding Factor; REX-1; Caveats of Using Reporters; Enrichment for Cancer Stem Cells Using Culture Media; Surface Markers Used for Enrichment and Analysis of Cancer Stem Cells; Acute Myelogenous Leukemia; Acute Lymphoblastic Leukemia; Chronic Myelogenous Leukemia; Breast Cancer; Colorectal Cancer; Liver Cancer; Pancreatic Cancer; Glioblastoma; Lung Cancer; Prostate Cancer; FUNCTIONAL ANALYSIS; Lineage Tracing.
In Vivo Lineage TracingGenetic Marking Methods in Transgenic Mouse Models; Lineage Tracing of Cancer Stem Cells In Vivo; Skin Papilloma; Intestinal Polyp; Medulloblastoma; Glioblastoma; Potential Utility of Genetic Marking Based on the Zygosity State; Lineage Tracing in Human Tumor Samples; In Vitro and In Vivo Tumor Formation and Clonogenic Assays; The Utility of Time-Lapse Video Microscopy for Cancer Stem Cell Studies; CONCLUSION AND FUTURE DIRECTIONS; List of Acronyms and Abbreviations; Acknowledgment; References; II -- CSCs in Representative Organ Systems.
4 -- Critical Updates to the Leukemia Stem Cell Model.
Summary This book introduces the basic concepts and advanced understanding of cancer stem cells, covering general overviews, organ-specific identifications, and their characteristic mechanisms. It also explores innovative therapeutic strategies in pre-clinical and clinical trials to target cancer stem cells, remove the roots of cancer, eliminate the seeds of metastasis, overcome the resistance of therapies, and contribute to the eradication of cancer.
Other Author Lathia, Justin Durla.
Other Title Print version: Liu, Huiping. Cancer stem cells. [London] : Academic Press is an imprint of Elsevier, 2016 9780128038925 0128038926