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Title Cell-extracellular matrix interactions in cancer / Roy Zent, Ambra Pozzi, editors.
Imprint New York : Springer, ©2010.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource (xii, 314 pages) : illustrations
Series 2010 Springer E-Books.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Cancer -- Pathophysiology.
Extracellular matrix proteins.
Neoplasms -- physiopathology.
Cell Communication.
Extracellular Matrix Proteins.
Contents The Extracellular Matrix: An Overview -- Integrin Structure and Function -- Cancer in Context: Importance of the Tumor Microenvironment -- Basement Membrane Collagens and Cancer -- Laminins and Cancer Progression -- Fibronectins and Their Receptors in Cancer -- Vitronectin-Binding Integrins in Cancer -- The Function of SPARC in Tumor Cell Biology: SPARC as a Modulator of Cell-Extracellular Matrix Interaction -- Proteoglycans and Cancer -- Tetraspanins in Cancer -- The Role of Integrin-Linked Kinase in Cancer Development and Progression -- Focal Adhesion Kinase with the Interacting Proteins and Signaling in Cancer.
Summary Cells require interactions with extracellular matrix (ECM) components in order to undergo normal morphogenesis with respect to organogenesis. ECM plays a significant role in regulating numerous cellular functions, like cell shape, adhesion, migration, proliferation, polarity, differentiation and apoptosis. In pathological conditions such as cancer, increased synthesis of certain ECM components and/or increased breakdown with consequent generation of ECM cleavage products can contribute to cancer growth and progression. That many growth factors (i.e. FGF, VEGF) are stored in the ECM milieu and are released upon protease-dependent cleavage further confirms the importance of ECM in regulating cell functions. Cell-Extracellular Matrix Interactions in Cancer describes how ECM creates a niche for tumor formation and the contribution of ECM components and their respective receptors in the development and spread of cancer.
Other Author Zent, Roy.
Pozzi, Ambra.
Other Title Print version: Cell-extracellular matrix interactions in cancer. New York : Springer, ©2010 9781441908131 1441908137