Limit search to items available for checkout
E-BOOK
Title Prions and prion diseases : new developments / Jean-Michel Verdier, editor.
Imprint New York : Nova Science Publishers, [2012]
©2012

Copies/Volumes

LOCATION CALL # STATUS
 Internet  Electronic Book    AVAILABLE
Description 1 online resource (ix, 200 pages) : illustrations (some color)
Series Protein biochemistry, synthesis, structure, and cellular functions
Protein science and engineering
Protein biochemistry, synthesis, structure, and cellular functions series.
Protein science and engineering.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Subject Prion diseases.
Prions.
Contents ""PRIONS AND PRION DISEASES""; ""PRIONS AND PRION DISEASES""; ""CONTENTS ""; ""PREFACE ""; ""NEUROPATHOLOGY OF HUMAN PRION DISEASES ""; ""ABSTRACT ""; ""INTRODUCTION ""; ""THE ROLE OF NEUROPATHOLOGY ""; ""PERFORMING THE AUTOPSY ""; ""NEUROPATHOLOGICAL EXAMINATION""; ""A.) Macroscopy""; ""B.) Work-Up for Histological Evaluation ""; ""C.) Microscopic Assessment ""; ""I.) Spongiform Change of the Neuropil ""; ""a) In Sporadic Forms""; ""b.) In Genetic Forms ""; ""c.) In Acquired Forms ""; ""II) Neuronal Death ""; ""a.) In Sporadic Forms ""; ""b.) In Genetic Forms ""; ""c.) In Acquired Forms ""
""SYNAPTIC PATHOLOGY """"III.) Astroglial Proliferation ""; ""IV.) Microglial Activation ""; ""V.) PrP Amyloid Plaques ""; ""a.) In Sporadic Forms ""; ""b.) In Genetic Forms ""; ""c.) In Acquired Forms ""; ""VI.) Cerebellar Pathology ""; ""a.) In Sporadic Forms ""; ""b.) In Genetic Forms ""; ""c.) In Acquired Forms""; ""RELATIVE RESISTANCE OF HIPPOCAMPUS IN CJD ""; ""VII.) Detection of PrP ""; ""VIIa.) By Immunohistochemistry ""; ""a.) In Sporadic Forms ""; ""b.) In Genetic Forms ""; ""c.) In Acquired Forms ""; ""VIIb.) By histoblot and Paraffin-Embedded Tissue Blot ""
""VIId.) By Western blot""""a.) In Sporadic Forms ""; ""b.) In Genetic Forms ""; ""c.) In Acquired Forms ""; ""VIII.) Co-deposition of other Abnormal Protein Aggregates in CJD ""; ""a) In Sporadic Forms ""; ""b) In Genetic Forms ""; ""c) In Acquired Forms ""; ""IX.) Differential Diagnoses from Autopsy Series ""; ""X.) Neuronal Systems and Their Clinico-Pathological Correlates ""; ""CONCLUSION ""; ""ACKNOWLEDGMENTS ""; ""REFERENCES ""; ""THE NATURE OF THE INFECTIOUS AGENTS: PRP MODELS OF RESISTANT SPECIES TO PRION DISEASES (DOG, RABBIT AND HORSES)""; ""Abstract""; ""1. Introduction""
""2. MaterialsandMethods""""3. ResultsandDiscussion""; ""4. Conclusion""; ""Acknowledgments""; ""References""; ""INDUCING TRANSMISSIBLE PRION DISEASES WITH RECOMBINANT FIBRILS: A NEW CONCEPT ON GENESIS AND EVOLUTION OF INFECTIOUS PRIONS ""; ""ABSTRACT ""; ""GENERATING TRANSMISSIBLE PRION DISEASES DE NOVO ""; ""THE MECHANISM OF TRIGGERING PRION DISEASE BY RPRP AMYLOID FIBRILS ""; ""EXPERIMENTAL EVIDENCE SUPPORT THE SECOND MODEL ""; ""THE HYPOTHESIS OF DEFORMED TEMPLATING ""; ""CONFORMATIONAL SWITCHING WITHIN INDIVIDUAL AMYLOID FIBRILS AND STRAIN ADAPTATION PHENOMENON""
""CROSS-TALK BETWEEN AMYLOIDOGENIC PROTEINS """"REFERENCES ""; ""SYNTHETIC PRIONS ""; ""ABSTRACT""; ""1. INTRODUCTION ""; ""2. STRATEGIES FOR DE NOVO MAMMALIAN PRIONS GENERATION ""; ""2.1. Cell-Free Assay Using Mammalian Prions ""; ""2.2. De Novo Generation of Prions by Mouse Transgenesis ""; ""2.3. In Vitro De Novo Prions by PMCA ""; ""2.4. De Novo Prions by Amyloid Seeding Assay ""; ""2.5. De Novo Prions by Annealing Technique ""; ""2.6. Concluding Remarks and New Emerging Techniques for Prion Detection and Generation ""; ""3. STRUCTURAL BIOLOGY OF NATURAL AND SYNTHETIC PRIONS""
Other Author Verdier, Jean-Michel.
Other Title Print version: 9781621000273 1621000273