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Title Histone deacetylases : transcriptional regulation and other cellular functions / edited by Eric Verdin.
Imprint Totowa, N.J. : Humana Press, ©2006.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource (xi, 340 pages) : illustrations (some color)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Histone deacetylase.
Cell cycle.
Cancer -- Chemotherapy.
Histone Deacetylases -- physiology.
Cell Cycle -- drug effects.
Enzyme Repression -- physiology.
Histone Deacetylase Inhibitors.
Neoplasms -- drug therapy.
Sirtuins -- physiology.
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Contents Histone deacetylase 1 / Dominique Meunier and Christian Seiser -- Biochemistry of multiprotein HDAC complexes / Alejandro Vaquero, Michael Scher, and Danny Reinberg -- The biology of HDAC3 / Edward Seto -- The biology of HDAC8, a unique class I histone deacetylase / David Waltregny and Vincent Castronovo -- Regulation of muscle gene expression by histone deacetylases / Timothy A. McKinsey and Eric N. Olson -- The class IIA histone deacetylases: functions and regulation / Herbert G. Kasler and Eric Verdin -- Histone deacetylases in the response to misfolded proteins / J. Andrew McKee and Tso-Pang Yao -- Evolution of sirtuins from archaea to vertebrates / Roy A. Frye -- Structure of the Sir2 family of NAD+-dependent histone/protein deacetylases / Kehao Zhao and Ronen Marmorstein -- The enzymology of Sir2 proteins / Margie T. Borra and John M. Denu -- The class III protein deacetylases: homologs of yeast Sir2P / Bjoern Schwer [and others] -- HDAC inhibitors: discovery, development, and clinical impacts / Akihiro Ito, Norikazu Nishino, and Mitsuaki Yoshida -- Cell cycle targets of histone deacetylase inhibitors / Brian Gabrielli -- HDAC inhibitors: an emerging anticancer therapeutic strategy / Paul Kwon, Meier Hsu, Dalia Cohen, and Peter Atadja.
Summary A panel of leading investigators summarizes and synthesizes the new discoveries in the rapidly evolving field of histone acetylation as a key regulatory mechanism for gene expression. The authors describe what has been learned about these proteins, including the identification of the enzymes, the elucidation of the enzymatic mechanisms of action, and the identification of their substrates and their partners. They also review the structures that have been solved for a number of enzymes - both alone and in complex with small molecule inhibitors - and the biological roles of the several histone d.
Other Author Verdin, Eric.
Other Title Print version: Histone deacetylases. Totowa, N.J. : Humana Press, ©2006 1588294994 9781588294999