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Title Statistical methods in drug combination studies / edited by Wei Zhao, MedImmune, LLC, Gaithersburg, Maryland, USA ; Harry Yang, MedImmune, LLC, Gaithersburg, Maryland, USA.
Imprint Boca Raton : CRC Press, [2015]


 Internet  Electronic Book    AVAILABLE
Description 1 online resource.
Series Chapman & Hall/CRC biostatistics series
Chapman & Hall/CRC biostatistics series.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Subject Drug development.
Drugs -- Research.
Drug Combinations.
Clinical Trials as Topic.
Models, Statistical.
Drug Design.
Drug Therapy, Combination.
Genre Electronic book.
Contents Drug combination : much promise and many hurdles / Harry Yang and Laura Richman -- Drug combination synergy / Harry Yang, Steven J. Novick, and Wei Zhao -- Drug combination design strategies / Steven J. Novick and John J. Peterson -- Confidence interval for interaction index / Maiying Kong and J. Jack Lee -- Two-stage response surface approaches to modeling drug interaction / Wei Zhao and Harry Yang -- A Bayesian industry approach to phase I combination trials in oncology / Beat Neuenschwander [and five others] -- Statistical methodology for evaluation combination therapy in clinical trials / H.M. James Hung, Sue-Jane Wang -- Challenges and opportunities in analysis of drug combination clinical trial data / Yaning Wang, Hao Zhu, Liang Zhao, and Ping Ji -- Statistical computational tools for ADA analysis / Cheng Su.
Summary Drug combination research has become increasingly important as multi-drug treatments may overcome disease resistance to monotherapies given the heterogeneous nature of complex diseases, such as cancer. To screen for potential candidates, rigorous statistical methods must used to avoid a high proportion of false-positive recommendations, resulting in a tremendous waste of time and resources. This book covers all statistical aspects of drug combination research, from designing in vitro drug combination studies to analyzing clinical trial data.
Other Author Zhao, Wei, 1975- editor.
Yang, Harry, editor.
Other Title Print version: Zhao, Wei. Statistical Methods in Drug Combination Studies. Hoboken : Taylor and Francis, ©2015 9781482216745