What do we mean when we write "senescence," "apoptosis," "necrosis," or "clearance of dying cells"? -- Apoptosis and autoimmune diseases -- Anti-inflammatory functions of the "apoptotic" caspases -- TAM receptors and the clearance of apoptotic cells -- ELMO1 signaling in apoptotic germ cell clearance and spermatogenesis -- Immune regulation by apoptotic cell clearance -- Role of class A human thrombospondins in the clearance of dying cells and tolerance induction -- Apoptotic mimicry: phosphatidylserine-mediated macropinocytosis of vaccinia virus -- Responding to infection and apoptosis: a task for TH17 cells -- Alpha (v) integrins license regulatory T cells to apoptotic cells and self-associated antigens -- Surface-exposed calreticulin in the interaction between dying cells and phagocytes -- Redox remodeling: a candidate regulator of HMGB1 function in injured skeletal muscle -- A role for calreticulin in the pathogenesis of rheumatoid arthritis -- Desirable cell death during anticancer chemotherapy -- Ex vivo- and in vivo-induced dead tumor cells as modulators of antitumor responses -- Intravenous apoptotic cell infusion as a cell-based therapy toward improving hematopoietic cell transplantation outcome.
"The mode of death and the clearance of dying cells has a tremendous impact on immune tolerance and alters the clearance of dying cells, which may lead to autoimmunity and persistent inflammation. Inflammatory and "dangerous" modes of death influence the process of clearance and have a crucial role in cancer and interaction with organisms that may mimic molecules appearing dying cells. These observation lead to the need of an exchange emphasizing the mammalian immune system in the context of diseases, such as inflammatory and autoimmune diseases, cancer, and infections. This volume explores a number of topics in this area including mechanisms of tolerance induction by dying cells; mechanisms of danger induction by dying cells; infection and clearance of dying cells; autoimmunity, inflammation and clearance of dying cells; clearance of dying cells in cancer; and clearance of dying cells in the pathogenesis of additional diseases."--Publisher website.