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E-BOOK
Title Cancer clinical trials : current and controversial issues in design and analysis / edited by Stephen L. George, Xiaofei Wang, Herbert Pang.
Imprint Boca Raton, FL : CRC Press, 2016.
©2016

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Description 1 online resource : illustrations
Series Chapman & Hall/CRC Biostatistics Series
Chapman & Hall/CRC biostatistics series.
Bibliog. Includes bibliographical references and index.
Note Legal Deposit; Only available on premises controlled by the deposit library and to one user at any one time; The Legal Deposit Libraries (Non-Print Works) Regulations (UK). WlAbNL
Available only to authorized UTEP users.
Restricted: Printing from this resource is governed by The Legal Deposit Libraries (Non-Print Works) Regulations (UK) and UK copyright law currently in force. WlAbNL
Print version record.
Subject Clinical trials -- Statistical methods.
Cancer -- Research.
Neoplasms.
Research.
Clinical Trials as Topic -- methods.
Contents 1. General issues -- 2. Early phase clinical trials -- 3. Late phase clinical trials -- 4. Personalized medicine.
Summary "Cancer Clinical Trials: Current and Controversial Issues in Design and Analysis provides statisticians with an understanding of the critical challenges currently encountered in oncology trials. Well-known statisticians from academic institutions, regulatory and government agencies (such as the U.S. FDA and National Cancer Institute), and the pharmaceutical industry share their extensive experiences in cancer clinical trials and present examples taken from actual trials. The book covers topics that are often perplexing and sometimes controversial in cancer clinical trials. Most of the issues addressed are also important for clinical trials in other settings. After discussing general topics, the book focuses on aspects of early and late phase clinical trials. It also explores personalized medicine, including biomarker-based clinical trials, adaptive clinical trial designs, and dynamic treatment regimes.-- Features: *Presents state-of-the-art approaches to the design and analysis of cancer clinical trials, such as adaptive designs, biomarker-based trials, and dynamic treatment regimes; *Explains the importance of selection of endpoints, use of historical data, multiplicity, analysis of safety data, discovery and validation of predictive signatures, dose-finding, sample size, and non-inferiority designs; *Includes contributions from top researchers in academia, government, and the industry; *Contains many examples drawn from real cancer clinical trials" -- Provided by publisher.
Other Author Wang, Xiaofei, editor.
Pang, Herbert, editor.
Other Title Print version: 9781498706889