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Title Statistical monitoring of clinical trials : a unified approach / Michael A. Proschan, K.K. Gordan Lan, Janet Turk Wittes.
Imprint New York, NY : Springer, ©2006.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource (xiii, 258 pages) : illustrations
Series Statistics for biology and health
Statistics for biology and health.
Bibliog. Includes bibliographical references (pages 247-254) and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Drugs -- Testing.
Clinical Trials -- statistics & numerical data
Bayes Theorem.
Data Interpretation, Statistical.
Contents Front Matter; Introduction; A General Framework; Power: Conditional, Unconditional, and Predictive; Historical Monitoring Boundaries; Spending Functions; Practical Survival Monitoring; Inference Following a Group-Sequential Trial; Options When Brownian Motion Does Not Hold; Monitoring for Safety; Bayesian Monitoring; Adaptive Sample Size Methods; Topics Not Covered; Appendix I: The Logrank and Related Tests; Appendix II: Group-Sequential Software; Back Matter.
Summary "The approach taken in this book is, to studies monitored over time, what the Central Limit Theorem is to studies with only one analysis. Just as the Central Limit Theorem shows that test statistics involving very different types of clinical trial outcomes are asymptotically normal, this book shows that the joint distribution of the test statistics at different analysis times is asymptotically multivariate normal with the correlation structure of Brownian motion ("the B-value") irrespective of the test statistic. The so-called B-value approach to monitoring allows us to use, for different types of trials, the same boundaries and the same simple formula for computing conditional power. Although Brownian motion may sound complicated, the authors make the approach easy by starting with a simple example and building on it, one piece at a time, ultimately showing that Brownian motion works for many different types of clinical trials."--Jacket.
Other Author Lan, K. K. Gordan.
Wittes, Janet Turk.
Other Title Print version: Proschan, Michael A. Statistical monitoring of clinical trials. New York, NY : Springer, ©2006 0387300597 9780387300597