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Title Advances in DNA repair in cancer therapy / Lawrence Panasci, Raquel Aloyz, Moulay Alaoui-Jamali, editors.
Imprint New York, NY : Humana Press, ©2013.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource
Series Cancer drug discovery and development ; 72
Cancer drug discovery and development ; 72.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Subject DNA repair.
Cancer -- Chemotherapy.
Cancer -- Genetic aspects.
DNA Repair.
Neoplasms -- genetics.
Neoplasms -- drug therapy.
Antineoplastic Agents -- therapeutic use.
biomedische wetenschappen
Medicine (General)
Geneeskunde (algemeen)
Contents Repair of DNA Interstrand Cross-links Produced by Cancer Chemotherapeutic Drugs / Anderson T. Wang, Peter J. McHugh -- DNA-PK, a Pharmacological Target in Cancer Chemotherapy and Radiotherapy? / Bernard Salles D.V.M., Ph. D. -- Growth Factor Receptor Signaling, DNA Damage Response, and Cancer Cell Susceptibility to Chemotherapy and Relapses / Moulay Alaoui-Jamali, Amine Saad, Gerald Batist -- The Relationship Between DNA-Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normal Tissues to Radiotherapy / David Murray, Matthew Parliament -- Important Roles of ERCC1 in DNA Repair and Targeted Therapy / Jennifer J. Hu, Joseph de la Garza -- The Role of BRCA1 and BRCA2 in Anticancer Drug Therapy / Andrew Y. Shuen, Jorge S. Reis-Filho -- DNA-PK in CLL Chemotherapy / L. Amrein, D. Davidson, R. Aloyz, L. Panasci -- Poly(ADP) Ribose Polymerase at the Interface of DNA Damage Signaling and DNA Repair / Jana Krietsch, Michèle Rouleau, Michel Lebel -- Cellular Protection Against the Antitumor Drug Bleomycin / Dindial Ramotar Ph. D., Mustapha Aouida Ph. D. -- ATR as a Therapeutic Target / Fiona K. Middleton, Nicola J. Curtin -- Telomeres, Telomerase, and DNA Damage Response in Cancer Therapy / Raina A. Tamakawa, Helen B. Fleisig -- RAD51 Is a Key Protein of DNA Repair and Homologous Recombination in Humans / Alexander V. Mazin Ph. D., Olga M. Mazina.
Summary This book deals with the emerging role of various DNA repair proteins and the regulatory elements which are implicated in cancer therapy such as DNA cross-linking agents, radiotherapy and bleomycin. The DNA repair genes discussed include those involved in BRCA/Rad51-related homologous recombinational repair, DNA-PK related nonhomologous endjoining and the nucleotide excision repair gene, ERCC1. Moreover, the role of regulatory genes such as PARP, ATR, telomerase, growth factor receptors and downstream kinase signalling is examined.
Other Author Panasci, Lawrence C.
Aloyz, Raquel.
Alaoui-Jamali, Moulay A.
Other Title Print version: Advances in DNA repair in cancer therapy. New York, NY : Humana Press, ©2013