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Title Camptothecin and camptothecin producing plants : botany, chemistry, anticancer activity and biotechnology / T. Pullaiah, P.B. Raghavendra, S. Karuppusamy, V. Raveendran, M. Anuradha.
Imprint London : Academic Press, 2020.

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 Internet  Electronic Book    AVAILABLE
Description 1 online resource
Note Includes index.
Available only to authorized UTEP users.
Subject Camptothecin.
Genre Electronic books.
Contents Front Cover -- Camptothecin and Camptothecin Producing Plants -- Copyright Page -- Contents -- Preface -- Abbreviations -- 1 Cancer biology and other disorders: beneficial role of camptothecin and novel derivatives -- 1.1 Introduction -- 1.2 The principles underlying transformation of normal cells into tumor -- 1.2.1 Self-sufficiency in growth signals -- 1.2.2 Insensitivity to antigrowth signals -- 1.2.3 Evading apoptosis -- 1.2.4 Limitless Replicative potential -- 1.2.5 Sustained angiogenesis -- 1.2.6 Tissue invasion and metastasis -- 1.3 Nuclear transcription factor kappa B
1.6.1 Deregulation of the apoptotic machinery -- 1.6.1.1 Expression of antiapoptotic proteins -- 1.6.1.2 Inactivation of proapoptotic genes -- 1.6.2 Drug influx and efflux -- 1.6.3 Drug inactivation -- 1.6.4 Drug targets -- 1.6.5 Alterations of the p53 pathway -- 1.6.6 DNA damage repair -- 1.6.7 Alterations in the survival signaling -- 1.6.8 Cell cycle events in context to antitumor agents -- 1.7 Strategy to overcome chemoresistance -- 1.7.1 Combination therapy -- 1.8 Camptothecin -- 1.8.1 Camptothecin and related derivatives-biological activity -- 1.8.1.1 Antitumor activity
1.8.1.2 Antiviral activity -- 1.8.1.3 Pesticidal activity -- 1.8.1.4 Antiparasitic activity -- 1.8.1.5 Antipsoriasis activity -- 1.8.1.6 Antifungal/antimicrobial activity -- 1.8.1.7 Hypoxia-inducible factor inhibitory activity -- 1.9 Conclusions -- References -- 2 Camptothecin: chemistry, biosynthesis, analogs, and chemical synthesis -- 2.1 Introduction -- 2.2 Chemistry of camptothecin -- 2.3 A historical account on the discovery of camptothecin -- 2.4 Plant sources of camptothecin -- 2.5 Factors affecting camptothecin production in plants -- 2.5.1 Nothopodytes
2.5.1.1 Geographical factors affecting camptothecin synthesis -- 2.5.1.2 Seasons -- 2.5.1.3 Plant parts -- 2.5.2 Ophiorrhiza -- 2.6 Camptothecin from endophytes -- 2.7 Biosynthetic pathway -- 2.8 Extraction of camptothecin -- 2.9 Clinically useful derivatives of camptothecin -- 2.9.1 Topotecan (hycamtin) -- 2.9.2 Irinotcan -- 2.9.3 Etirinotecan pegol, a conjugate of irinotecan -- 2.10 Analogs of camptothecin under clinical investigation -- 2.10.1 Rubitecan -- 2.10.2 Exatecan -- 2.10.3 FL118, a novel structurally similar analog of camptothecin -- 2.10.4 Gimatecan -- 2.10.5 Morpholinocamptothecin
Other Author Pullaiah, T.
Other Title Original 0128204990 9780128204993