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E-BOOK
Title Clinical trials in rheumatoid arthritis and osteoarthritis / David M. Reid, Colin G. Miller, editors.
Imprint London : Springer, ©2008.

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Description 1 online resource (viii, 325 pages) : illustrations
Series Clinical Trials
Clinical Trials.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Rheumatoid arthritis -- Treatment.
Osteoarthritis -- Treatment.
Clinical trials.
Arthritis, Rheumatoid -- drug therapy.
Clinical Trials as Topic.
Osteoarthritis -- drug therapy.
Contents Introduction / David M. Reid and Colin G. Miller -- Historical and Current Perspectives on Management of Osteoarthritis and Rheumatoid Arthritis / Shirish Dubey and Adewale O. Adebajo -- Development of Biological Therapies for Inflammatory Arthritis / Neil Basu -- Study Design and End Points for Rheumatoid Arthritis Trials / Pieter Geusens and Colin G. Miller -- Study Design and End Points in Ankylosing Spondylitis Clinical Trials / Désirée van der Heijde -- Trial Design and Outcomes in Osteoarthritis / Nigel Arden -- Ethical Considerations / Derek Pearson and Colin G. Miller -- Organization of the Clinical Trial by the Sponsor / Colin G. Miller --Organization of the Trial at the Investigator Site / Julie Shotton, David M. Reid, and Colin G. Miller -- Role of the Imaging Core Laboratory in Rheumatoid Arthritis and Osteoarthritis Clinical Trials / Mark D. Endres and Anna M. Baratelle -- Biochemical Markers of Rheumatoid Arthritis and Osteoarthritis: Clinical Utility and Practical Considerations / Mario R. Ehlers and Elizabeth T. Leary -- Data Analysis and Presentation: Writing a Paper for Publication / Derek Pearson -- Radiographic Imaging End Points in Rheumatoid Arthritis Trials / Anna M. Baratelle and Désirée van der Heijde -- Radiography in Clinical Trials Investigating Osteoarthritis / Cornelis van Kuijk -- Use of Quantitative Magnetic Resonance Imaging in the Cross-Sectional and Longitudinal Evaluation of Structural Changes in Knee Osteoarthritis Patients / Jean-Pierre Raynauld, Johanne Martel-Pelletier, François Abram, and Jean-Pierre Pelletier -- Biochemical Markers as Surrogate End Points of Joint Disease / L. Stefan Lohmander and David R. Eyre -- Role of Genetics and Genomics in Clinical Trials in Osteoarthritis and Rheumatoid Arthritis / Stuart H. Ralston -- Cost-Effectiveness of New Biologics for Rheumatoid Arthritis and Osteoarthritis / Yolanda Bravo Vergel and David Torgerson.
Summary Designed to be a practical handbook on clinical trial management in these key therapeutic areas, Clinical Trials in Rheumatoid Arthritis and Osteoarthritis is aimed at principal investigators, pharmaceutical physicians and other pharmaceutical staff involved in the design, conduct and monitoring of these increasingly complex diseases. In the last several years a new classes of biologic agents have emerged and changed the treatment paradigm for patients, not only with classically defined rheumatoid arthritis, but also with other related diseases such as ankylosing spondylitis and psoriatic arthritis. Furthermore, osteoarthritis is a major disease state that is often treated by the rheumatologist, but is one where patient management programs are currently limited with a need for new therapeutic approaches. In both inflammatory and non-inflammatory arthritic conditions, clinical trials have become both large and complex due to the nature of the diseases, with ever-challenging new surrogate end-points being employed. Topics covered in this title will therefore include study design, clinical endpoints, technical issues, data collection, use of centralized medical image reading facilities and biochemical marker laboratories, as well as data analysis and future therapies. This book takes the user through the process step-by-step from start to finish, also providing a background on the regulatory guidelines, ethical implications, endpoints, and current therapies.
Other Author Reid, David, 1951-
Miller, Colin G., 1960-
Other Title Print version: Clinical trials in rheumatoid arthritis and osteoarthritis. London : Springer, ©2008 9781852338749 1852338741