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Title Adaptive design methods in clinical trials / Shein-Chung Chow, Mark Chang.
Imprint Boca Raton, FL : CRC Press, ©2012.


 Internet  Electronic Book    AVAILABLE
Edition 2nd ed.
Description 1 online resource (xvi, 358 pages) : illustrations
Series Chapman & Hall/CRC biostatistics series
Chapman & Hall/CRC biostatistics series.
Note "A Chapman & Hall book."
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Clinical trials.
Adaptive sampling (Statistics)
Experimental design.
Clinical trials -- Statistical methods.
Clinical Trials as Topic -- methods.
Research Design.
Biometry -- methods.
Models, Statistical.
Contents Protocol amendment -- Adaptive randomization -- Adaptive hypotheses -- Adaptive dose-escalation trials -- Adaptive group sequential design -- Statistical tests for adaptive seamless designs -- Adaptive sample size adjustment -- Two-stage adaptive design -- Adaptive treatment switching -- Bayesian approach -- Biomarker adaptive trials -- Target clinical trials -- Sample size and power estimation -- Clinical trial simulation -- Regulatory perspectives : a review of FDA draft guidance.
Summary With new statistical and scientific issues arising in adaptive clinical trial design, including the U.S. FDA's recent draft guidance, a new edition of one of the first books on the topic is needed. Adaptive Design Methods in Clinical Trials, Second Edition reflects recent developments and regulatory positions on the use of adaptive designs in clinical trials. It unifies the vast and continuously growing literature and research activities on regulatory requirements, scientific and practical issues, and statistical methodology. New to the Second Edition Along with revisions throughout the text.
Other Author Chang, Mark.
Other Title Print version: Chow, Shein-Chung, 1955- Adaptive design methods in clinical trials. 2nd ed. Boca Raton, FL : CRC Press, ©2012 9781439839874