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E-BOOK
Title Simulation for designing clinical trials : a pharmacokinetic-pharmacodynamic modeling perspective / [edited by] Hui C. Kimko, Stephen B. Duffull.
Imprint New York : Marcel Dekker, ©2003.

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Description 1 online resource (xviii, 396 pages) : illustrations.
Series Drugs and the pharmaceutical sciences ; v. 127
Drugs and the pharmaceutical sciences ; v. 127.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Drugs -- Testing -- Computer simulation.
Clinical trials -- Computer simulation.
Drugs -- Design -- Computer simulation.
Models, Theoretical.
Pharmacokinetics.
Clinical Trials -- methods.
Genre Electronic book.
Contents Foreword; Preface; Contents; Contributors; Introduction to Simulation for Design of Clinical Trials; Input-Output Models; Defining Covariate Distribution Models for Clinical Trial Simulation; Protocol Deviations and Execution Models; Determination of Model Appropriateness; Computational Considerations in Clinical Trial Simulations; Analysis of Simulated Clinical Trials; Sensitivity Analysis of Pharmacokinetic and Pharmacodynamic Models in Clinical Trial Simulation and Design; Choice of Best Design; Clinical Trial Simulation (CTS); Academic Perspective.
Summary This text details essential components of performing simulation for designing clinical trials via pharmacokinetic-pharmacodynamic modelling. It offers a range of applications for optimizing sampling strategies, selecting dosage and predicting drug efficacy and side-effects.
Other Author Kimko, Hui C., 1964-
Duffull, Stephen B., 1964-
Other Title Print version: Simulation for designing clinical trials. New York : Marcel Dekker, ©2003 0824708628