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001    965350260 
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005    20200921045118.8 
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007    cr |n||||||||| 
008    161122s2015    flua    ob    001 0 eng d 
020    9781498717472 
020    1498717470 
024 7  10.1201/b18532 
035    (OCoLC)965350260|z(OCoLC)963347655|z(OCoLC)963719839
       |z(OCoLC)964569186 
035    Taylor & Francis All eBooks 
035    skip4alma 
037    TANDF_391441|bIngram Content Group 
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082 04 610.72/4|223eb 
100 1  Chang, Mark,|eauthor. 
245 10 Introductory adaptive trial designs :|ba practical guide 
       with R /|cMark Chang. 
264  1 Boca Raton :|bCRC Press,|c[2015] 
300    1 online resource (xiii, 218 pages) :|billustrations 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
490 1  Chapman & Hall/CRC biostatistics series 
504    Includes bibliographical references and index. 
505 0  Front Cover; Contents; Preface; 1. Introduction; 2. 
       Classical Design; 3. Two-Stage Adaptive Confirmatory 
       Design Method; 4. K-Stage Adaptive Confirmatory Design 
       Methods; 5. Sample-Size Reestimation Design; 6. Special 
       Two-Stage Group Sequential Trials; 7. Pick-the-Winners 
       Design; 8. The Add-Arms Design; 9. Biomarker-Adaptive 
       Design; 10. Response-Adaptive Randomization; 11. Adaptive 
       Dose-Escalation Trial; 12. Deciding Which Adaptive Design 
       to Use; 13. Monitoring Trials and Making Adaptations; 14. 
       Data Analyses of Adaptive Trials; 15. Planning and 
       Execution. 
505 8  Appendix A: Thirty-Minute Tutorial to RAppendix B: R 
       Functions for Adaptive Designs; Bibliography. 
506    Available only to authorized UTEP users. 
520 3  All the Essentials to Start Using Adaptive Designs in No 
       Time Compared to traditional clinical trial designs, 
       adaptive designs often lead to increased success rates in 
       drug development at reduced costs and time. Introductory 
       Adaptive Trial Designs: A Practical Guide with R motivates
       newcomers to quickly and easily grasp the essence of 
       adaptive designs as well as the foundations of adaptive 
       design methods. 
588 0  Print version record. 
650  0 Clinical trials|xDesign. 
650  0 Clinical trials|xComputer simulation. 
650  0 Clinical trials|xStatistical methods. 
650  0 Adaptive sampling (Statistics) 
650  0 R (Computer program language) 
650 12 Clinical Trials as Topic. 
650 22 Research Design. 
650 22 Models, Statistical. 
776 08 |iPrint version:|z9781498717465|z1498717462|w(DLC)  
       2015458268|w(OCoLC)907196331 
830  0 Chapman & Hall/CRC biostatistics series. 
856 40 |uhttp://0-www.taylorfrancis.com.lib.utep.edu/books/
       9780429158940|zTo access this resource 
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