LEADER 00000cam  2200709Ia 4500 
001    714584881 
003    OCoLC 
005    20200921044052.5 
006    m     o  d         
007    cr cnu---unuuu 
008    110425s2011    flua    obf   001 0 eng d 
020    9781439810170 
020    1439810176 
035    (OCoLC)714584881|z(OCoLC)705865078 
035    Taylor & Francis All eBooks 
035    skip4alma 
037    TANDF_204652|bIngram Content Group 
040    N$T|beng|epn|cN$T|dE7B|dSINTU|dYDXCP|dCUS|dOCLCQ|dOCLCF
       |dUA@|dOCL|dOCLCQ|dUAB|dSTF|dOCLCQ|dNLE|dUKMGB|dWYU|dYDX
       |dTYFRS|dLEAUB|dUUM|dOCLCO|dOCLCA 
049    txum 
050  4 R853.C55|bH355 2011eb 
072  7 HEA|x032000|2bisacsh 
072  7 MED|x034000|2bisacsh 
072  7 HEA|x009000|2bisacsh 
072  7 OCC|x011000|2bisacsh 
082 04 615.5072/4|222eb 
245 00 Handbook of adaptive designs in pharmaceutical and 
       clinical development /|cedited by Annpey Pong, Shein-Chung
       Chow. 
246 30 Adaptive designs in pharmaceutical and clinical 
       development 
260    Boca Raton :|bCRC Press,|c©2011. 
300    1 online resource (1 volume (various pagings)) :
       |billustrations 
336    text|btxt|2rdacontent 
337    computer|bc|2rdamedia 
338    online resource|bcr|2rdacarrier 
504    Includes bibliographical references and index. 
505 0  1. Overview of adaptive design methods in clinical trials 
       / Annpey Pong and Shein-Chung Chow -- 2. Fundamental 
       theory of adaptive designs with unplanned design change in
       clinical trials with blinded data / Qing Liu and George 
       Y.H. Chi -- 3. Bayesian approach for adaptive design / 
       Guosheng Yin and Ying Yuan -- 4. The impact of protocol 
       amendments in adaptive trial designs / Shein-Chung Chow 
       and Annpey Pong -- 5. From group sequential to adaptive 
       designs / Christopher Jennison and Bruce W. Turnbull -- 6.
       Determining sample size for classical designs / Simon 
       Kirby and Christy Chuang-Stein -- 7. Sample size 
       reestimation design with applications in clinical trials /
       Lu Cui and Xiaoru Wu -- 8. Adaptive interim analyses in 
       clinical trials / Gernot Wassmer -- 9. Classical dose-
       finding trial / Naitee Ting -- 10. Improving dose-finding 
       : a philosophic view / Carl-Fredrik Burman, Frank Miller, 
       and Kiat Wee Wong -- 11. Adaptive dose-ranging studies / 
       Marc Vandemeulebroecke [and others] -- 12. Seamless phase 
       I/II designs / Vladimir Dragalin -- 13. Phase II/III 
       seamless designs / Jeff Maca -- 14. Sample size estimation
       /allocation for two-stage seamless adaptive trial designs 
       / Shein-Chung Chow and Annpey Pong -- 15. Optimal response
       -adaptive randomization for clinical trials / Lanju Zhang 
       and William Rosenberger -- 16. Hypothesis-adaptive design 
       / Gerhard Hommel -- 17. Treatment adaptive allocations in 
       randomized clinical trials : an overview / Atanu Biswas 
       and Rahul Bhattacharya -- 18. Integration of predictive 
       biomarker diagnostics into clinical trials for new drug 
       development / Richard Simon -- 19. Clinical strategy for 
       study endpoint selection / Siu Keung Tse, Shein-Chung Chow,
       and Qingshu Lu -- 20. Adaptive infrastructure / Bill Byrom,
       Damian McEntegart, and Graham Nicholls. 
505 8  21. Independent data monitoring committees / Steven 
       Snapinn and Qi Jiang -- 22. Targeted clinical trials / Jen
       -Pei Liu -- 23. Functional genome-wide association studies
       of longitudinal traits / Jiangtao Luo [and others] -- 24. 
       Adaptive trial simulation / Mark Chang -- 25. Efficiency 
       of adaptive designs / Nigel Stallard and Tim Friede -- 26.
       Case studies in adaptive design / Ning Li, Yonghong Gao, 
       and Shiowjen Lee -- 27. Good practices for adaptive 
       clinical trials / Paul Gallo. 
506    Available only to authorized UTEP users. 
520    "This comprehensive guide offers a unified presentation of
       the principles and methodologies in adaptive design and 
       analysis. It gives a well-balanced summary of current 
       regulatory perspectives and recently developed statistical
       methods in this area. The handbook provides some insight 
       regarding early phase and later phase adaptive designs. 
       With a focus on the implementation of adaptive methods in 
       clinical trials, it introduces the concepts of role, 
       responsibility, function, and activity of a data safety 
       monitoring board (DSMB) when applying these methods. Other
       important topics covered in detail include regulatory 
       perspectives and logistics issues in applying adaptive 
       design methods"--Provided by publisher. 
588 0  Print version record. 
650  0 Clinical trials|vHandbooks, manuals, etc. 
650  0 Drugs|xResearch|xMethodology|vHandbooks, manuals, etc. 
650 12 Clinical Trials as Topic|xmethods. 
650 22 Research Design. 
650 22 Statistics as Topic|xmethods. 
655  0 Electronic books. 
655  7 Handbooks and manuals.|2fast|0(OCoLC)fst01423877 
700 1  Pong, Annpey. 
700 1  Chow, Shein-Chung,|d1955- 
776 08 |iPrint version:|tHandbook of adaptive designs in 
       pharmaceutical and clinical development.|dBoca Raton, : 
       CRC Press, ©2011|z9781439810163|w(DLC)  2010037121
       |w(OCoLC)660509874 
856 40 |uhttp://0-www.taylorfrancis.com.lib.utep.edu/books/
       9780429130663|zTo access this resource 
LOCATION CALL # STATUS
 Internet  Electronic Book    AVAILABLE