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E-BOOK
Title Design and analysis of cross-over trials / Byron Jones, Michael G. Kenward.
Imprint Boca Raton, Florida : CRC Press, 2015.
©2015

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LOCATION CALL # STATUS
 Internet  Electronic Book    AVAILABLE
Edition Third edition.
Description 1 online resource (431 pages) : illustrations
Series Chapman & Hall Book
Monographs on Statistics and Applied Probability ; 138
Monographs on statistics and applied probability (Series) ; 138.
Bibliog. Includes bibliographical references.
Note Available only to authorized UTEP users.
Print version record.
Subject Crossover trials.
Clinical Trials as Topic -- methods.
Cross-Over Studies.
Research Design.
Genre Electronic books.
Contents 1. Introduction -- 2. The 2x2 cross-over trial -- 3. Higher-order for two treatments -- 4. Designing cross-over trials -- 5. Analysis of continuous data -- 6. Analysis of discrete data -- 7. Bioequivalence trials -- 8. Case study : phase I dose-response noninferiority trial -- 9. Case study : choosing a dose-response model -- 10. Case study : conditional power -- 11. Case study : proof of concept trial with sample size re-estimation -- 12. Case study : blinded sample size re-estimation in a bioequivalence study -- 13. Case study : unblinded sample size re-estimation in a bioequivalence study that has a group sequential design -- 14. Case study : various methods for an unblinded sample size re-estimation in a bioequivalence study.
Summary "Since the publication of the second edition, there has been significant research and development in cross-over trials, which continue to be an important design technique in the pharmaceutical industry. This new edition has been updated with recent references and new material on analysis of small trials, analysis of baseline measurements, bioequivalence, cross-over trials in early phase drug development, and adaptive cross-over trials. The book includes numerous real examples, including some new data sets to illustrate the methods described, with SAS code available for their implementation"-- Provided by publisher.
Other Author Kenward, Michael G., 1956- author.
Other Title Print version: Jones, Byron. Design and analysis of cross-over trials. Third edition. Boca Raton, Florida : CRC Press, ©2015 xxvi, 403 pages Monographs on statistics and applied probability (Series) ; 138 9781439861424