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Title Cured : how the Berlin patients defeated HIV and forever changed medical science / Nathalia Holt.
Imprint New York, New York : Dutton, [2014]


 Main Stacks  RA643.86.G2 H65 2014    AVAILABLE
Description xxi, 313 pages ; 24 cm
Bibliog. Includes bibliographical references (pages 273-295) and index.
Subject HIV infections -- Treatment -- Germany -- Berlin.
Gene therapy -- Germany -- Berlin -- History.
HIV Infections -- therapy -- Germany.
Anti-HIV Agents -- Germany -- history.
Anti-HIV Agents -- therapeutic use -- Germany.
Genetic Therapy -- Germany -- history.
History, 20th Century -- Germany.
History, 21st Century -- Germany.
Hydroxyurea -- Germany -- history.
Hydroxyurea -- therapeutic use -- Germany.
Treatment Outcome -- Germany.
Contents A doctor, two patients, and some tests. The good doctor in denial ; A visit with the family doctor ; Death sentence? -- The disease, a drug, and its industry. Viral Trojan horse ; A weapon from the war on cancer ; The days of acting up ; Recognizing a global pandemic ; From the one percent ; But, Doctor, I don't feel sick ; The Delta 32 Mutation ; Calling all elite controllers ; Treatment in hiding -- Treating the Berlin patients. The second diagnosis ; The compassionate use exemption ; Three deadly diseases move in ; The comfort of family and strangers ; Timing ; Transplanting ; "Perhaps we have eradicated HIV" ; An unexciting recovery -- The cure. Trials ; Proof of principle ; The good doctor in court ; Not even surprising ; The promise kept ; A child cured-- so what? ; Zinc finger snap ; The abused, the respected, and relentless.
Summary A young molecular biologist at the forefront of HIV research, Nathalia Holt tells the historic, multilayered, and compassionate story of two patients--each known in medical literature as the Berlin Patient--and their young research-minded doctors. The backdrop is nothing less than a revolution in cultural attitudes and medical thinking. These two patients' disparate cures came twelve years apart: the first in 1996 from an experimental cancer drug, the other in 2008 from a bone marrow transplant of cells with a particular genetic mutation. Holt connects the molecular dots of these two cases for the first time, providing insight into one of the most important medical breakthroughs of our generation.