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E-BOOK
Title Diagnostic and prognostic biomarkers and therapeutic targets in melanoma / Michael J. Murphy, editor.
Imprint New York, NY : Humana Press, ©2012.

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 Internet  Electronic Book    AVAILABLE
Description 1 online resource (xiv, 322 pages) : illustrations
Series Current clinical pathology
Current clinical pathology.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Subject Melanoma -- Diagnosis.
Tumor markers -- Diagnostic use.
Melanoma -- Pathogenesis.
Biochemical markers.
Melanoma -- diagnosis.
Drug Delivery Systems.
Drug Design.
Drug Therapy.
Melanoma -- therapy.
Biomarkers, Tumor.
geneeskunde
volksgezondheid
public health
dermatologie
oncologie
pathologie
Medicine (General)
Geneeskunde (algemeen)
Contents Introduction to diagnostic and prognostic biomarkers and therapeutic targets in melanoma -- Diagnostic and prognostic biomarkers in melanoma: current state of play -- Molecular pathogenesis of melanoma: established andnovel pathways -- Staging of melanoma -- Clinical and histopathologocial paramenters in melanoma -- Genetic/epigentic biomarkers: distinction of melanoma from other melanocytic neoplasms -- mRNA biomarkers in melanoma -- Epigenetic biomarkers in melanoma -- MicroRNA biomarkers in melanoma -- MciroRNAs as biomarkers and therapeutic targets in melanoma -- Mitochondrial DNA biomarkers in melanoma -- Tissue-based protein biomarkers in melanoma: immunohistochemistry: (A) diagnosis -- Tissue-based protein biomarkers in melanoma: immunohistochemistry: (B) prognostication -- Tissue-based protein biomarkers in melanoma: mass spectrometry-based strategies -- Serological biomarkers in melanoma -- Molecular markers of lymph node disease in melanoma -- Melanoma cell propagation: cancer stem cell, clonal evolution and interconversion models of tumorigenicity -- Surgical management of melanoma: concept of field cancerization and molecular evaluation of tissue margins -- Chemotherapy for melanoma -- Molecular-targeted therapy for melanoma -- Anti-angiogenesis therapy for melanoma -- Immunological biomarkers and immunotherapy for melanoma -- Diagnostic and prognostic biomarkers and therapeutic targets in melanoma: an overview.
Summary This book describes both the technologies used in the discovery of melanoma biomarkers and the clinical application of these biomarkers for diagnosis and staging of disease, determination of prognosis, treatment planning, monitoring of response to therapy, identification of novel therapeutic targets and drug development. A broad range of biomarkers (DNA/chromosomal, mRNA, microRNA, mitochondrial DNA, epigenetic and protein) is outlined. As therapies for melanoma become increasingly more target specific, the identification, validation and use of biomarkers will invariably play a greater role in the management of patients with this disease. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma is an essential resource for oncologists, dermatologists, dermatopathologists, general pathologists with an interest in melanoma, and melanoma researchers.
Other Author Murphy, Michael J., 1969-
Other Title Print version: Diagnostic and prognostic biomarkers and therapeutic targets in melanoma. New York, NY : Humana Press, ©2012