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Title Biomarkers in breast cancer : molecular diagnostics for predicting and monitoring therapeutic effect / edited by Giampietro Gasparini and Daniel F. Hayes.
Imprint Totowa, N.J. : Humana Press, ©2006.

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Description 1 online resource (xi, 341 pages)
Series Cancer drug discovery and development
Cancer drug discovery and development.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Breast -- Cancer -- Molecular diagnosis.
Breast -- Cancer -- Prognosis.
Tumor markers.
Breast Neoplasms -- diagnosis.
Molecular Diagnostic Techniques.
Biomarkers, Tumor.
neoplasms
biomedische wetenschappen
biomedicine
Medicine (General)
Geneeskunde (algemeen)
Contents Guidelines for the design of clinical studies for the development and validation of therapeutically relevant biomarkers and biomarker-based classification systems / Richard M. Simon -- Analytical aspects of biomarker immunoassays in cancer research / C.G.J. (Fred) Sweep, Chris M.G. Thomas and Manfred Schmitt -- Tissue microarrays: state-of-the-art, pitfalls, and promises / Chungyeul Kim and Soonmyung Paik -- Gene expression profiling with DNA microarrays / Michele De Bortoli and Nicoletta Biglia -- Assays for gene amplification / Chungyeul Kim, Yongkuk Song, and Soonmyung Paik -- Cell kinetics / Maria Grazia Daidone, Rosella Silvestrini, and Dino Amadori -- Urokinase-type plasminogen activator and PAI-1 / Michael J. Duffy -- Predictive value of c-erbb-2 for endocrine therapy and chemotherapy in breast cancer / Vered Stearns -- Erb-b-2 as a therapeutic target / Robert Mass -- The epidermal growth factor receptor pathway as a selective -- Molecular-targeting treatment in human breast cancer / Fortunato Ciardiello, Teresa Troiani, and Giampaolo Tortora -- P-53 as a prognostic and predictive indicator / Daniela Kandioler and Raimund Jakesz -- Occult metastatic cells in breast cancer patients / Stephan Braun, Julia Seeber, and Christian Marth -- Circulating HER-2/neu / Allan Lipton [and others] -- Circulating vascular endothelial growth factor / Roberta Sarmiento [and others] -- Detection of early tumor dissemination in patients with breast cancer / Debra Hawes and Richard J. Cote -- New technologies/new markers/new challenges / Daniel F. Hayes and Giampietro Gasparini -- Index.
Summary Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth fact.
Other Author Gasparini, Giampietro.
Hayes, Daniel, 1951-
Other Title Print version: Biomarkers in breast cancer. Totowa, N.J. : Humana Press, ©2006 1588292274 9781588292278