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Title Therapeutic resistance to anti-hormonal drugs in breast cancer : new molecular aspects and their potential as targets / edited by Stephen Hiscox, Julia Gee, Robert I. Nicholson.
Imprint Dordrecht ; London : Springer, 2009.

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Description 1 online resource (1 volume)
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Breast -- Cancer -- Chemotherapy.
Drug resistance in cancer cells.
Breast Neoplasms.
Drug Resistance, Neoplasm.
Biomarkers, Tumor.
Contents Experimental endocrine resistance: concepts and strategies / Robert I. Nicholson, Iain R. Hutcheson, Stephen Hiscox, Kathy M. Taylor and Julia M.W. Gee -- Transcriptional coactivators and corepressors in endocrine response and resistance in breast cancer / Simak Ali -- The re-expression of estrogen receptor in estrogen receptor-negative breast cancer and restoration of anti-estrogen responses / Jill Bayliss, Amy Hilger, Prakash Vishnu, Kathleen Diehl and Dorraya El-Ashry -- The dark side of antihormonal action in breast cancer / Julia M.W. Gee, Andrew Stone, Richard A. McClelland, Stephen Hiscox, Iain R. Hutcheson, Nicola J. Jordan, Heidi M. Fiegl, Martin Widschwendter, Victoria E. Shaw, Denise Barrow and Robert I. Nicholson -- Influence of the tumour microenvironment / Rosemary A. Walker -- Are stem-like cells responsible for resistance to therapy in breast cancer? / Ciara S. O'Brien, Gillian Farnie, Sacha J. Howell and Robert B. Clarke -- HSP90 inhibition as an anticancer strategy: novel approaches and future directions / Marissa V. Powers and Paul Workman -- Adverse features of acquired antihormone resistance and their targeting / Stephen Hiscox, Nicola Jordan, Liam Morgan, Chris Smith, Lindy Goddard, Julia M.W. Gee and Robert I. Nicholson -- Identifying modifiers of tamoxifen sensitivity using high-throughput gGenetic and chemical screens / Elizabeth Iorns, Christopher J. Lord and Alan Ashworth -- Endocrine resistance in breast cancer -- Where are we now with intelligent combination therapies? / Stephen R.D. Johnston.
Summary Covers the molecular details and functional consequences of endocrine resistance in breast cancer with particular emphasis on the future applications of novel drug combinations that may be utilized to circumvent resistance and improve anti-tumour effects. This book is suitable for clinicians and researchers alike.
Other Author Hiscox, Stephen.
Gee, Julia.
Nicholson, Robert I.
Other Title Springer eBooks
Print version: Therapeutic resistance to anti-hormonal drugs in breast cancer. Dordrecht ; London : Springer, 2009 9781402085253 1402085257