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Clofibric Acid.   2001 1
 

Clofibrinic Acid -- See Clofibric Acid


An antilipemic agent that is the biologically active metabolite of CLOFIBRATE.
  1
 

Clonal Deletion -- See Also Apoptosis


A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically-programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
  1
 

Clonal Selection, Antigen-Mediated -- See Also Antibody Formation


The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
  1
Clone Cells.   4
Clone Cells -- immunology.   2
 

Clones -- See Clone Cells


A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
  1
 

Complex Partial Seizure -- See Seizures


Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."
  1
 

Cloning, Embryo -- See Cloning, Organism


The formation of one or more genetically identical organisms derived by vegetative reproduction from a single cell. The source nuclear material can be embryo-derived, fetus-derived, or taken from an adult somatic cell.
  1
 

Cloning, Human -- See Cloning, Organism


The formation of one or more genetically identical organisms derived by vegetative reproduction from a single cell. The source nuclear material can be embryo-derived, fetus-derived, or taken from an adult somatic cell.
  1
  Cloning, Molecular -- 4 Related Mesh   4
Cloning, Molecular.   20
Cloning, Molecular -- Congresses.   2
Cloning, Molecular -- history.   c1981 1
Cloning, Molecular -- Laboratory Manuals.   1989 1
Cloning, Molecular -- Legislation.   1997 1
Cloning, Molecular -- methods.   5
Cloning, Molecular -- methods -- Periodicals.   2
Cloning, Molecular -- Periodicals.   2009 1
  Cloning, Organism -- 3 Related Mesh   3
Cloning, Organism.   13
Cloning, Organism -- ethics.   7
Cloning, Organism -- legislation & jurisprudence.   2
Cloning, Organism -- methods.   3
Cloning, Organism -- moral & ethical aspects.   1999 1
Cloning, Organism -- Moral and ethical aspects -- United States.   2002 1
Cloning, Organism -- United States.   10
 

Cloning Vectors -- See Genetic Vectors


DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
  1
 

Clonogenic Cell Assay -- See Colony-Forming Units Assay


A cytologic technique for measuring the functional capacity of stem cells by assaying their activity.
  1
 

Cloranfenicol -- See Chloramphenicol


An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)
  1
Close Air Support -- history.   1997 1
Close Air Support -- United States.   1992 1
 

Close-Contact Infectious Disease Transmission -- See Disease Transmission, Infectious


The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
  1
 

Close-Contact Transmission -- See Disease Transmission, Infectious


The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal or vertical (INFECTIOUS DISEASE TRANSMISSION, VERTICAL).
  1
 

Close, William Herbert -- See Close, Bill


  1
 

Closed Cohort Studies -- See Cohort Studies


Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
  1
 

Closed Ecologic Life Support Systems -- See Ecological Systems, Closed


Systems that provide for the maintenance of life in an isolated living chamber through reutilization of the material available, in particular, by means of a cycle wherein exhaled carbon dioxide, urine, and other waste matter are converted chemically or by photosynthesis into oxygen, water, and food. (NASA Thesaurus, 1988)
  1
Closterovirus.   2019 1
 

Clostridial Neurotoxin -- See Tetanus Toxin


Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ̃150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
  1
Clostridioides difficile.   2
 

Clostridium botulinum -- See Also Botulinum Toxins


Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
  1
Clostridium botulinum -- Congresses.   1970 1
Clostridium botulinum -- pathogenicity.   2007 1
 

Clostridium botulinum Toxins -- See Botulinum Toxins


Toxic proteins produced from the species CLOSTRIDIUM BOTULINUM. The toxins are synthesized as a single peptide chain which is processed into a mature protein consisting of a heavy chain and light chain joined via a disulfide bond. The botulinum toxin light chain is a zinc-dependent protease which is released from the heavy chain upon ENDOCYTOSIS into PRESYNAPTIC NERVE ENDINGS. Once inside the cell the botulinum toxin light chain cleaves specific SNARE proteins which are essential for secretion of ACETYLCHOLINE by SYNAPTIC VESICLES. This inhibition of acetylcholine release results in muscular PARALYSIS.
  1
Clostridium -- chemistry.   1993 1
 

Clostridium difficile -- See Clostridioides difficile


A common inhabitant of the colon flora in human infants and sometimes in adults. The type species Clostridioides difficile is formerly known as Clostridium difficile. It is a causative agent for CLOSTRIDIOIDES INFECTIONS and is associated with PSEUDOMEMBRANOUS ENTEROCOLITIS in patients receiving antibiotic therapy.
  1
Clostridium Infections -- veterinary.   2016 1
Clostridium -- pathogenicity.   2016 1
 

Clostridium tetani -- See Also Tetanus Toxin


Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ̃150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
  1
 

Clostridium tetani Toxin -- See Tetanus Toxin


Protein synthesized by CLOSTRIDIUM TETANI as a single chain of ̃150 kDa with 35% sequence identity to BOTULINUM TOXIN that is cleaved to a light and a heavy chain that are linked by a single disulfide bond. Tetanolysin is the hemolytic and tetanospasmin is the neurotoxic principle. The toxin causes disruption of the inhibitory mechanisms of the CNS, thus permitting uncontrolled nervous activity, leading to fatal CONVULSIONS.
  1
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