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Title Translational research methods for diabetes, obesity and cardiometabolic drug development : a focus on early phase clinical studies /dc Andrew J. Krentz, Lutz Heinemann, Marcu Hompesch, editors.
Imprint London ; New York : Springer, [2015]


 Internet  Electronic Book    AVAILABLE
Description 1 online resource
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Online resource; title from PDF title page (Ebsco, viewed Dec. 15, 2014).
Subject Drug development.
Diabetes -- Treatment.
Obesity -- Treatment.
Diabetes Mellitus -- drug therapy.
Obesity -- drug therapy.
Clinical Trials, Phase I as Topic -- methods.
Clinical Trials, Phase II as Topic -- methods.
Translational Medical Research.
metabolic disorders
public health
Medicine (General)
Geneeskunde (algemeen)
Genre Electronic books.
Contents 1. Review of physiology/pathophysiology -- 2. Methods for assessing insulin action in humans -- 3. Assessment of insulin secretion -- 4. Measurement of ectopic fat in liver and muscle using magnetic resonance spectroscopy -- 5. Isotopic tracers for the measurement of metabolic flux -- 6. Measuring food intake in clinical drug development -- 7. Measurement of energy expenditure -- 8. Assessment of body composition -- 9. Assessment of cardiovascular safety of new diabetes drugs.
Machine generated contents note: pt. I Review of Clinical Investigation Methodologies -- 1. Methods for Quantifying Insulin Sensitivity and Determining Insulin Time-Action Profiles / Marcus Hompesch -- 2. Assessment of β-Cell Function / Marcus Hompesch -- 3. Isotopic Tracers for the Measurement of Metabolic Flux Rates / Scott M. Turner -- 4. Imaging Techniques for the Assessment of Ectopic Fat in Liver and Skeletal Muscle / Claude B. Sirlin -- 5. Positron-Emission Tomography and Computed Tomography Measurement of Brown Fat Thermal Activation: Key Tools for Developing Novel Pharmacotherapeutics for Obesity and Diabetes / Alex DeCastro -- 6. Assessment of Body Composition / Paul R. Clark -- 7. Measurement of Energy Expenditure / Klaas R. Westerterp -- 8. Omics: Potential Role in Early-Phase Drug Development / Christian Gieger -- pt. II Emerging and Complementary Research Methods; Ethical and Regulatory Considerations -- 9. Early Phase Metabolic Research with Reference to Special Populations / Andrew J. Krentz -- 10. Quantitative Approaches in Translational Research: An Overview / Stephan Schmidt -- 11. Computational Modelling of Energy Metabolism and Body Composition Dynamics / Kevin D. Hall -- 12. Regulatory Considerations for Early Clinical Development of Drugs for Diabetes, Obesity, and Cardiometabolic Disorders / G. Alexander Fleming.
Summary This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
Other Author Krentz, Andrew J., editor.
Heinemann, Lutz, editor.
Hompesch, Marcus, editor.
Other Title Print version: Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development. Springer Verlag 2014 9781447149194