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Title BCL-2 protein family : essential regulators of cell death / edited by Claudio Hetz.
Imprint New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2010.

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Description 1 online resource (xvii, 145 pages) : illustrations
Series Advances in experimental medicine and biology ; v. 687
Advances in experimental medicine and biology ; v. 687.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Print version record.
Subject Apoptosis.
Tumor proteins.
Proto-Oncogene Proteins c-bcl-2 -- metabolism.
Proto-Oncogene Proteins c-bcl-2 -- physiology.
Apoptosis -- physiology.
Neoplasms -- metabolism.
Neoplasms -- pathology.
Contents Homeostatic functions of BCL-2 proteins beyond apoptosis / Nika N. Danial, Alfredo Gimenez-Cassina, and Daniel Tondera -- Alternative functions of the BCL-2 protein family at the endoplasmic reticulum / Diego Rojas-Rivera [and others] -- BH3-only proteins and their effects on cancer / Thanh-Trang Vo and Anthony Letai -- Endoplasmic reticulum stress and BCL-2 family members / Ross T. Weston and Hamsa Puthalakath -- Targeting survival pathways in lymphoma / Luca Paoluzzi and Owen A. O'Connor -- The interplay between BCL-2 family proteins and mitochondrial morphology in the regulation of apoptosis / Maria Eugenia Soriano and Luca Scorrano -- Noncanonical functions of BCL-2 proteins in the nervous system / Heather M. Lamb and J. Marie Hardwick -- Mitochondria on guard : role of mitochondrial fusion and fission in the regulation of apoptosis / Mariusz Karbowski.
Summary In this book, scientists pioneering the field have compiled a series of focused chapters to highlight the relevance of the BCLa'2 family of proteins in apoptosis, physiology and disease. An important focus of this volume is considering the potential therapeutic benefits of targeting apoptosis pathways in the context of human disease. Readers interested in understanding how a cell handles stress and the consequences of dysregulation of this process for human disease will find this book very valuable. It attempts to describe a fascinating area of research where physiology and biomedicine converg.
Other Author Hetz, Claudio.
Other Title Print version: BCL-2 protein family. New York : Springer Science+Business Media ; Austin, Tex. : Landes Bioscience, ©2010 9781441967053