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Title Protein aggregation and fibrillogenesis in cerebral and systemic amyloid disease / J. Robin Harris, editor.
Imprint Dordrecht ; New York : Springer, ©2012.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource
Series Subcellular biochemistry, 0306-0225 ; 65
Sub-cellular biochemistry ; 65.
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Subject Amyloid beta-protein.
Aggregation (Chemistry)
Amyloidosis -- physiopathology.
Cell Aggregation.
Plague, Amyloid
Protein Folding.
Biochemical Phenomena.
Cell Movement.
Physical Phenomena.
Metabolic Diseases.
Cell Physiological Phenomena.
Amino Acids, Peptides, and Proteins
Macromolecular Substances.
Chemical Phenomena.
Pathological Conditions, Signs and Symptoms
Nutritional and Metabolic Diseases
Chemicals and Drugs
Phenomena and Processes
Plaque, Amyloid.
Proteostasis Deficiencies.
Biophysical Phenomena.
Multiprotein Complexes.
Pathological Conditions, Anatomical
Contents Introduction and technical survey: Protein aggregation and fibrillogenesis -- Fibril formation by short synthetic peptides -- In vitrooligomerization and fibrillogenesis of amyloid-beta peptides -- Tau fibrillogenesis -- Prion protein aggregation and fibrillogenesisin vitro -- Alpha-synuclein aggregation and modulating factors -- Pathological self-aggregation of [beta](2)-microglobulin: A challenge for protein biophysics -- Islet amyloid polypeptide: Aggregation and fibrillogenesisin vitroand its inhibition -- Mechanisms of transthyretin aggregation and toxicity -- Fibrillogenesis of huntingtin and other glutamine containing proteins -- Aggregation and fibrillogenesis of proteins not associated with disease: A few case studies -- Experimental inhibition of peptide fibrillogenesis by synthetic peptides, carbohydrates and drugs -- Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (abeta) and other disease-related peptides/proteins by plant extracts and herbal compounds -- Alzheimer's disease -- Modeling the polyglutamine aggregation pathway in huntington's disease: From basic studies to clinical applications -- Parkinson's disease -- Human prion diseases: From kuru to variant creutzfeldt-jakob disease -- Animal prion diseases -- [beta](2)-microglobulin amyloidosis -- Systemic AA amyloidosis -- Familial amyloidotic polyneuropathy and transthyretin -- The challenge of systemic immunoglobulin light-chain amyloidosis (AL).
Introduction -- Introduction and Technical Survey: Protein Aggregation and Fibrillogenesis / J. Robin Harris, Nathaniel G.N. Milton -- Basic Science -- Fibril Formation by Short Synthetic Peptides / Andrew Smith -- In vitroOligomerization and Fibrillogenesis of Amyloid-beta Peptides / Núria Benseny-Cases, Oksana Klementieva, Josep Cladera -- Tau Fibrillogenesis / Nitin Chaudhary, Ramakrishnan Nagaraj -- Prion Protein Aggregation and FibrillogenesisIn Vitro / Jan Stöhr -- α-Synuclein Aggregation and Modulating Factors / Katerina E. Paleologou, Omar M.A. El-Agnaf -- Pathological Self-Aggregation ofb2-Microglobulin: A Challenge for Protein Biophysics / Gennaro Esposito, Alessandra Corazza, Vittorio Bellotti -- Islet Amyloid Polypeptide: Aggregation and Fibrillogenesisin vitroand Its Inhibition / Janine Seeliger, Roland Winter -- Mechanisms of Transthyretin Aggregation and Toxicity / Robert J. Gasperini, David W. Klaver, Xu Hou, Marie-Isabel Aguilar, David H. Small -- Fibrillogenesis of Huntingtin and Other Glutamine Containing Proteins / Yuri L. Lyubchenko, Alexey V. Krasnoslobodtsev, Sorin Luca -- Aggregation and Fibrillogenesis of Proteins not Associated with Disease: A Few Case Studies / Moritz Lassé, Juliet A. Gerrard, F. Grant Pearce -- Experimental Inhibition of Peptide Fibrillogenesis by Synthetic Peptides, Carbohydrates and Drugs / Alagiri Srinivasan -- Experimental Inhibition of Fibrillogenesis and Neurotoxicity by amyloid-beta (Aβ) and Other Disease-Related Peptides/Proteins by Plant Extracts and Herbal Compounds / Suresh Kumar, Edward J. Okello, J. Robin Harris -- Clinical Science: The Cerebral and Systemic Amyloid Diseases -- Alzheimer's Disease / Vanessa J. De-Paula, Marcia Radanovic, Breno S. Diniz, Orestes V. Forlenza -- Modeling the Polyglutamine Aggregation Pathway in Huntington's Disease: From Basic Studies to Clinical Applications / Keizo Sugaya -- Parkinson's Disease / Timothy R. Mhyre, James T. Boyd, Robert W. Hamill, Kathleen A. Maguire-Zeiss -- Human Prion Diseases: From Kuru to Variant Creutzfeldt-Jakob Disease / Beata Sikorska, Pawel P. Liberski -- Animal Prion Diseases / Otto Windl, Mike Dawson -- β2-Microglobulin Amyloidosis / Dorthe B Corlin, Niels H.H. Heegaard -- Systemic AA Amyloidosis / Jennifer H. Pinney, Helen J. Lachmann -- Familial Amyloidotic Polyneuropathy and Transthyretin / Takamura Nagasaka -- The Challenge of Systemic Immunoglobulin Light-Chain Amyloidosis (AL) / Giovanni Palladini, Raymond L. Comenzo.
Summary This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer's disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer's disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, t.
Other Author Harris, J. Robin (James Robin)
Other Title Print version: 9781283936118