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Title Systems genetics : methods and protocols / edited by Klaus Schughart, Robert W. Williams.
Imprint New York : Humana Press : Springer, ©2017.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource (xiv, 609 pages) : illustrations (some color)
Series Methods in molecular biology, 1064-3745 ; 1488
Methods in molecular biology (Clifton, N.J.) ; v. 1488. 1064-3745
Bibliog. Includes bibliographical references and index.
Note Available only to authorized UTEP users.
Online resource; title from PDF title page (SpringerProtocol, viewed December 9, 2016).
Subject Genetics -- Laboratory manuals.
Systems biology -- Laboratory manuals.
Systems Biology -- methods.
Genre Laboratory Manual.
Laboratory manuals.
Contents Resources for systems genetics / Robert W. Williams and Evan G. Williams -- Heterogeneous stock populations for analysis of complex traits / Leah C. Solberg Woods and Richard Mott -- Mouse genome informatics (MGI) : resources for mining mouse genetic, genomic, and biological data in support of primary and translational research / Janan T. Eppig, Cynthia L. Smith, Judith A. Blake, Martin Ringwald, James A. Kadin, Joel E. Richardson, and Carol J. Bult -- GeneNetwork : a toolbox for systems genetics / Megan K. Mulligan, Khyobeni Mozhui, Pjotr Prins, and Robert W. Williams -- Complex trait analyses of the collaborative cross : tools and databases / Ramesh Ram and Grant Morahan -- Integrative functional genomics for systems genetics in / Jason A. Bubier, Michael A. Langston, Erich J. Baker, and Elissa J. Chesler -- Suite of tools for biologists that improve accessibility and visualization of large systems genetics datasets : applications to the hybrid mouse diversity panel / Christoph D. Rau, Mete Civelek, Calvin Pan, and Aldons J. Lusis -- Expression QTLs mapping and analysis : a bayesian perspective / Martha Imprialou, Enrico Petretto, and Leonardo Bottolo -- Epigenetics and control of RNAs / Henrike Maatz, Sebastiaan van Heesch, Franziska Kreuchwig, Allison Faber, Eleonora Adami, Norbert Hubner, and Matthias Heinig -- Integrating multidimensional data sources to identify genes regulating complex phenotypes / Rupert W. Overall -- RNA-Seq in the collaborative cross / Richard Green, Courtney Wilkins, Martin T. Ferris, and Michael Gale Jr. -- QTL mapping and identification of candidate genes in DO mice : a use case model derived from a benzene toxicity experiment / Dan Gatti, John E. French, and Klaus Schughart -- Visualization of results from systems genetics studies in chromosomal context / Karen Y. Oróstica and Ricardo A. Verdugo -- Using baseline transcriptional connectomes in rat to identify genetic pathways associated with predisposition to complex traits / Laura Saba, Paula Hoffman, and Boris Tabakoff -- Precise network modeling of systems genetics data using the bayesian network webserver / Jesse D. Ziebarth and Yan Cui -- Systems genetics as a tool to identify master genetic regulators in complex disease / Aida Moreno-Moral, Francesco Pesce, Jacques Behmoaras, and Enrico Petretto -- Genomic control of retinal cell number : challenges, protocol, and results / Patrick W. Keeley, Irene E. Whitney, and Benjamin E. Reese -- Systems genetics analysis to identify the genetic modulation of a glaucoma-associated gene / Sumana R. Chintalapudi and Monica M. Jablonski -- Genetic dissection of variation in hippocampal intra- and infrapyramidal mossy fibers in the mouse / Anna Delprato and Wim E. Crusio -- Complex genetics of cardiovascular traits in mice : F2-mapping of QTLs and their underlying genes / Svitlana Podliesna, Connie R. Bezzina, and Elisabeth M. Lodder -- Systems genetics of liver fibrosis / Rabea A. Hall and Frank Lammert -- Systems genetics analysis of iron and its regulation in brain and periphery / Byron C. Jones and Leslie C. Jellen -- Systems genetics of obesity / Gudrun A. Brockmann, Danny Arends, Sebastian Heise, and Ayca Dogan -- Social interactions and indirect genetic effects on complex juvenile and adult traits / David G. Ashbrook and Reinmar Hager -- Complex genetics of behavior : BXDs in the automated home-cage / Maarten Loos, Matthijs Verhage, Sabine Spijker, and August B. Smit -- Integrative analysis of genetic, genomic, and phenotypic data for ethanol behaviors : a network-based pipeline for identifying mechanisms and potential drug targets / James W. Bogenpohl, Kristin M. Mignogna, Maren L. Smith, and Michael F. Miles -- Dissection of host susceptibility to bacterial infections and its toxins / Aysar Nashef, Mahmoud Agbaria, Ariel Shusterman, Nicola Ivan Lorè, Alessandra Bragonzi, Ervin Wiess, Yael Houri-Haddad, and Fuad A. Iraqi -- Collaborative cross resource for systems genetics research of infectious diseases / Paul L. Maurizio and Martin T. Ferris -- Using systems genetics to understanding the etiology of complex disease / Ramesh Ram and Grant Morahan.
Summary This volume focuses on the use of system genetic methods and the use of murine models to study the role of gene variants and environmental factors on human health and disease--what is now often called personalized or precision health care. The protocols in this book will help readers analyze genetic causes of heritable variation across a wide range of systems and traits using rodent models. The chapters in this book are separated into three sections that cover: 1) resources for systems genetics; 2) tools for analysis and integration in systems genetics; and 3) systems genetics use cases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and tools, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Systems Genetics: Methods and Protocols is a valuable resource for anyone who is interested in this diverse field.
Other Author Schughart, Klaus, editor.
Williams, Robert W., editor.
Other Title Printed edition: 9781493964253