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Title Stem cell proliferation and differentiation [electronic resource] / edited by Thomas G. Fazzio.
Imprint Cambridge, MA : Academic Press, 2020.


 Internet  Electronic Book    AVAILABLE
Description 1 online resource.
Series Current Topics in Developmental Biology ; 138.
Current topics in developmental biology ; 138.
Note Available only to authorized UTEP users.
Subject Stem cells.
Cell proliferation.
Cell differentiation.
Stem Cells.
Cell Differentiation.
Cell Proliferation.
Contents Intro -- Stem Cell Proliferation and Differentiation -- Copyright -- Contents -- Contributors -- Preface -- 1. Chromatin regulation and dynamics -- 2. Long noncoding RNAs and RNA-binding proteins -- 3. Distinct modes of pluripotency -- 4. Differentiation of pluripotent stem cells -- 5. Metabolic control of cell state -- 6. Conclusions and perspectives -- Chapter One: Chromatin regulation and dynamics in stem cells -- 1. Chromatin compaction, structure, and function -- 1.1. Nucleosomes are formed from DNA interacting with an octamer of four histone proteins.
1.2. Chromatin structure balances DNA compaction and accessibility -- 2. Chromatin dynamics regulate gene expression -- 3. ATP-dependent nucleosome remodeling complexes establish and maintain chromatin state -- 3.1. SWI/SNF family nucleosome remodeling factors -- 3.2. INO80 family nucleosome remodeling factors -- 3.3. ISWI family nucleosome remodeling factors -- 3.4. CHD family nucleosome remodeling factors -- 3.5. Summary -- 4. Histone modifications provide an additional layer of gene regulation -- 4.1. Histone acetylation and deacetylation -- 4.2. Histone methylation and demethylation.
4.3. Polycomb group proteins mediate H3K27me3 and silencing of developmental genes -- 5. Histone chaperones and histone variants regulate chromatin structure -- 6. Histone H2A variants -- 6.1. H2A.Z is a histone variant associated with active transcription -- 6.2. H2A.X is a marker of DNA double-strand breaks -- 6.3. macroH2A is associated with repression and heterochromatin -- 7. Histone H3 variants -- 7.1. H3.3 marks regulatory, repetitive, and actively transcribed regions -- 7.2. CENP-A is a centromere-specific variant of histone H3 -- 8. Histone chaperones.
8.1. FACT facilitates H2A/H2B dimer exchange to promote nucleosome-templated activities -- 8.2. CAF1 and ASF1 promote incorporation of H3 and H4 onto newly synthesized DNA -- 8.3. HIRA deposits H3.3 at actively transcribed and regulatory regions of chromatin -- 8.4. ATRX/DAXX deposit H3.3 at telomeres and pericentric heterochromatin -- 8.5. The NAP1 family import newly translated histones from the cytoplasm to the nucleus -- 8.6. INO80 family members possess both nucleosome remodeling and histone chaperone activities -- 9. Chromatin structure is dynamic and highly regulated.
10. Stem cell chromatin is dynamic and tuned to regulate cell fate -- 11. ES cells carefully regulate their chromatin via specialized transcription factors -- 11.1. Master regulators of pluripotency -- 11.2. Pioneer transcription factors -- 12. Embryonic stem cell chromatin is poised for action -- 13. Histone modifications are specifically regulated in stem cells to maintain pluripotency and facilitate differentiation -- 13.1. H3K56ac regulates pluripotency factors and developmental regulators -- 13.2. Bivalent promoters mark lowly expressed but poised genes in ES cells.
Other Author Fazzio, Thomas G.
Other Title Print version: 0128128909 9780128128909